The impact of particular stressors varies across different people.  Death or other losses such as a job layoffs; relationship difficulties like divorce; normal milestones such as puberty, marriage, or retirement; alcoholism or drug abuse; neurochemical and hormonal imbalances; and infections can all be powerful enough to cause depressive symptoms in someone with a diathesis for this illness. However, each of these events will impact individuals in a unique manner. A significant loss may be enough to trigger depression in one person, while a very similar loss experienced by another person might not faze them all that much.

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